Formyl-Selective Deuteration of Aldehydes with D2O via Synergistic Organic and Photoredox Catalysis
Qingmin Wang describes the catalyzed formyl-selective deuteration of aldehydes.
In recent years, interest in the incorporation of deuterium atoms into patented drugs and drug candidates to enhance their metabolism and pharmacokinetic properties has burgeoned. After FDA approval of the first deuterated drug, deutetrabenazine (Austedo), the demand for such compounds increased significantly and has motivated the development of efficient deuteration methods. Professor Qingmin Wang from the State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University (P. R. of China) mentioned that “the development of an efficient protocol for constructing formyl-deuterated aromatic aldehydes can be expected to increase the availability of deuterated lead compounds.” Herein he presents a practical method for latestage modification of synthetic intermediates in medicinal chemistry and for generating libraries of deuterated compounds.