SYNLETT Best Paper Award 2022: A Photoenzyme for Challenging Lactam Radical Cyclizations
Todd Hyster gives further insights to his award-winning paper on lactam radical cyclizations using a photoenzyme.
The award-winning article presents the use of engineered enzymes that pre-organize radical substrates in a confined active site to selectively engage in chemical reactions. Todd Hyster and his group from Cornell University (Ithaca, USA) provide a beautiful and general solution to the longstanding problem of controlling the selectivity of radical reactions. The authors proof the superiority of their photoenzymatic approach by comparing it to methods with traditional tin hydride and more modern methods such as iron hydride and photoredox catalysis.
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