Iron-Catalyzed Intermolecular Amination of Benzylic C(sp3)–H Bonds

Buddhadeb Chattopadhyay describes the intermolecular C(sp3)–H amination and its applications.

Benzyl amines are important motifs in organic chemistry owing to their extensive use in medicinal chemistry, drug discovery and materials science. Professor Buddhadeb Chattopadhyay’s group from the Centre of Biomedical Research (CBMR) in Lucknow (India) has a strong interest in developing synthetic methods for accessing complex and functionalized benzyl amine frameworks. Professor Chattopadhyay explained that “many top-selling marketed drugs such as Rivastigmine, Cinacalcet, Tripelennamine, and many more, contain benzyl amine functionalities. While various enzymatic and chemical synthetic methodologies are available for installing an amine functionality, development of a new catalytic process for direct installation of the amine group at a selected C–H bond of an organic molecule remains a vibrant area of research in medicinal and bio-organic chemistry.”

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