Kinetic Resolution of Cyclic Benzylic Azides Enabled by Site- And Enantioselective C(sp3)–H Oxidation
Lei Liu presents the kinetic resolution of cyclic benzylic azides by C(sp3)–H oxidation.
Site- and enantioselective oxidation of aliphatic C–H bonds with a general scope, predictable selectivities and in preparatively useful yields, would represent a paradigm shift in the standard logic of organic synthesis. On the other hand, catalytic kinetic resolution (KR) of racemates is one of the most powerful and practical tools to prepare valuable enantiopure targets, which predominantly relies on the manipulation of reactive functional groups. The group of Professor Lei Liu at Shandong University (Jinan, P. R. of China) envisioned that integrating the KR strategy into enantioselective C(sp3)–H oxidation reaction design would advance the development of both research fields.