Detailed Comparison of Nickel vs. Palladium in Cross-Coupling Catalysis

Nickel versus Palladium in Cross-Coupling Catalysis: On the Role of Substrate Coordination to Zerovalent Metal Complexes: A. K. Cooper, P. M. Burton, D. J. Nelson
Synthesis 2020, 52, 565–573


Metal-catalyzed cross-coupling reactions have become a major tool in the arsenal of organic chemists and the Suzuki–Miyaura synthesis of biaryls is one of the most used reactions in organic chemistry. Despite its popularity and extensive use, a detailed comparison of the effect of coordinating functional groups on the reactivity of different metal catalysts – such as nickel and palladium – on the performance of the Suzuki–Miyaura reaction had not yet been presented. This gap has now been filled by a report from the group of Professor David J. Nelson from the University of Strathclyde (Glasgow, UK).

Professor Nelson said: “As chemists look to implement nickel-catalyzed cross-coupling reactions in a range of scenarios in academia and industry it is important to understand how nickel can interact with functional groups that are likely to be present within complex substrates.”

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