Synthesis of Novel Imidazothiadiazoles

Peter Langer presents a new protocol for the synthesis of fused imidazothiadiazoles.

Synthesis of 1,3,4-Thiadiazolo[2′,3′:2,3]imidazo[4,5-b]indoles: B. Jafari, S. Safarov, M. Khalikova, P. Ehlers, P. Langer
Synlett 2019, DOI: 10.1055/s-0039-1690147

Imidazothiadiazoles are heterocyclic compounds displaying a broad range of biological activities, spanning from anti-bacterial to anti-inflammatory and anti-cancer. Although several reports on the synthesis of functionalized imidazothiadiazoles are present in the literature, examples of palladium-mediated syntheses are rare. Recently, the group of Professor Peter Langer from the University of Rostock (Germany) reported a new protocol for the synthesis of a new class of fused imidazothiadiazoles, relying on an efficient Buchwald–Hartwig ring-closure amination of a dibromo precursor with different anilines.


Professor Langer said: “Novel 1,3,4-thiadiazolo[2’,3’:2,3]imidazo[4,5-b]indoles were prepared in a straightforward way.”

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