Construction of Azaheterocycles via Pd-Catalyzed Migratory Cycloannulation Reaction of Unactivated Alkenes
Peng Wang presents the synthesis of azaheterocycles starting from unactivated alkenes.
Azaheterocycles, which are among the most prominent structural units in medicinal chemistry, are prevalent in small molecule drugs and bioactive compounds. Therefore, methodologies for the efficient construction of azaheterocycle-containing molecules are in high demand. Among the reported synthetic methods to access these compounds, the Larock annulation – which exploits the cycloannulation of ambiphilic arylhalides with carbon–carbon double bonds – is one of the most widely used and promising strategies. The group of Professor Peng Wang from the Shanghai Institute of Organic Chemistry (P. R. of China) has recently introduced the concept of the Pd-catalyzed migratory cycloannulation strategy as a novel approach for building up a range of diverse sizes of azaheterocycles.