Photochemical Diversification of Strong C(sp3)–H Bonds Enabled by Allyl Bromide and Sodium Fluoride
Lei Gong shows the use of allyl bromide and NaF in photochemical C–H functionalization reactions.
The direct functionalization of C(sp3)–H bonds has become a hot research topic and has been recognized as one of the most convenient approaches to increase the value of cheap raw chemical materials in synthetic chemistry due to its atom- and step-economy. Professor Lei Gong from Xiamen University (P. R. of China) explains that “the high bond-dissociation energies, low polarity and similar chemical environments for alkane C(sp3)–H bonds mean that the available methods often rely on harsh reaction conditions with strong redox systems, or expensive and sophisticated catalysts, which limits the industrial applications.” Therefore, he is interested in the exploration of convenient methods to realize the cost-effective and mild C–H bond functionalization of alkanes. In this current study, his group developed a new strategy for the diversification of strong C(sp3)–H bonds enabled by allyl bromide and sodium fluoride under visible-light irradiation.