Reductive Dearomative Arylcarboxylation of Indoles with Carbon Dioxide via Visible-Light Photoredox Catalysis
Da-Gang Yu describes the photoredox-catalyzed reductive dearomative arylcarboxylation of indoles.
The catalytic reductive coupling of two electrophiles with one unsaturated bond represents an economic and efficient way to construct complex molecular skeletons, which is commonly achieved by transition-metal-catalyzed two-electron-transfer reactions. However, the latter almost invariably suffer from chemoselectivity issues, which are caused by side reactions of the in situ generated organometallic reagents, including β-H elimination and ipso direct coupling. Inspired by the merits of visible-light photoredox catalysis, the group of Professor Da-Gang Yu from Sichuan University (Chengdu, P. R. of China), has recently reported a novel strategy relying on visible-light photoredox-catalyzed successive single-electron transfer (SSET), thus accomplishing the first example of dearomative arylcarboxylation of indoles with CO2.