Palladium-Catalyzed One-Pot Stereospecific Synthesis of 2-Deoxy Aryl C-Glycosides from Glycals and Anilines in the Presence of tert-Butyl Nitrite
Jeyakumar Kandasamy reports a Pd-catalyzed stereospecific synthesis of 2-deoxy aryl C-glycosides.
The lay person generally understands carbohydrates as a source of energy, but these compounds are also an important class of biomolecules which have been investigated as drugs, vaccines, drug targets, diagnostic tools, and more. Unlike other biomolecules, such as proteins and nucleic acids, carbohydrates are complex in nature not only because of their structure and stereochemistry, but also because of their manifold biological functions. Complex carbohydrates such as polysaccharides are known as glycans, which can be broadly classified as O- and C-glycosides depending on their anomeric linkages. The group of Dr. Jeyakumar Kandasamy at the Indian Institute of Technology (Varanasi, India) has been studying these classes of molecules and recently published the title paper on the one-pot synthesis of 2-deoxy aryl C-glycosides.