Synthesis of Medicinally Relevant Oxalylamines via Copper/Lewis Acid Synergistic Catalysis
Huanfeng Jiang and Wanqing Wu describe a Cu/Lewis acid catalyzed synthesis of medicinally relevant oxalylamines.
Allylamines, especially those with easy-to-transform function al groups, are a critically important class of building blocks in the fields of organic synthesis and medicinal chemistry. Typically, these compounds are also versatile synthetic intermediates in the atom-economical construction of alkaloids, amino acids, and complex natural products. Professor Huanfeng Jiang from the South China University of Technology (Guangzhou, P. R. of China) explains that “transition-metalcatalyzed amination of olefins is an atomeconomical pathway to construct ubiquitous C–N bonds.” His research interests focus on the construction of C–C and C–X (X = O, N, S, etc.) bonds of unsaturated hydrocarbons catalyzed by transition metals with green oxidants. Here, his group presents the synthesis of useful oxalylamines via copper/Lewis acid synergistic catalysis.