Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids Including Totally Substituted Butenolides and Pyrroles
Takaaki Sato describes the synthesis and anti-inflammatory activity of stemoamide-type alkaloids.
Tricyclic stemoamide has been recognized as a very popular target for total synthesis. Indeed, many research groups have reported the total synthesis of this relatively simple natural product to demonstrate the utility of their own synthetic method. However, none had accomplished the total synthesis of the pentacyclic stemoamide-type natural products, despite the fact that pentacyclic protostemonine is known to show much better biological profiles, such as protective effects on acute liver failure and acute lung injury in mice. Some time ago, the group of Professor Takaaki Sato at Keio University (Yokohama, Japan) started a project that led to the publication of this highlighted paper.