Cyclodepsipeptide Alveolaride C: Total Synthesis and Structural Assignment

Rajib Kumar Goswami presents the total synthesis of cyclodepsipeptide alveolaride C.

Alveolarides are a class of agriculturally important cyclodepsipeptides, which were isolated from cultures of the fungus Microascus alveolaris in 2018 by researchers at Dow AgroS ciences (DAS) in the USA who partially elucidated the structures of alveolarides A–C. These are 17-membered macrocyclic compounds having the rarely found 2,3-dihydroxy-4-methyltetradecanoic acid (DHMTDA) as the common nonpeptide unit. The stereochemistry of asymmetric centers on the DHMTDA segment remained unassigned. The group of Professor Rajib Kumar Goswami at the Indian Association for the Cultivation of Science (Jadavpur, India) has targeted alveolaride C with the intention of solving the mystery of its structural assignment using total synthesis as the key tool.

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