11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C–H Functionalizations
Mingji Dai presents the first total synthesis of anticancer natural product hamigeran M.
Advances in the field of C–H functionalization have brought revolutionary changes in the total synthesis of natural products. Direct functionalizations of C–H bonds in complex structural settings can significantly enhance synthetic efficiency and economy by avoiding preliminary functional group installations and subsequent manipulations. The group of Professor Mingji Dai from Purdue University (West Lafayette, USA) has been developing innovative strategies and methodologies to facilitate the total synthesis and biological profiling of complex bioactive natural products. They recently reported the first total synthesis of the anticancer natural product hamigeran M.