Unified Metal-Free Intermolecular Heck-type Sulfonylation, Cyanation, Amination, Amidation of Alkenes by Thianthrenation
Wei Shu reports on various metal-free intermolecular Heck-type reactions of alkenes by thianthrenation.
Carbon–carbon double bonds are ubiquitous in organic molecules and are among the most valuable functional groups for orthogonal derivatization in organic synthesis. Given the synthetic versatility of alkenes, their functionalization represents a highly important research topic. According to Professor Wei Shu from the Southern University of Science and Technology (SUSTech), P. R. of China, the Heck reaction is one of the most prominent and effective methods for direct functionalization of the C–H bond of alkenes in this area. He added: “Typically, Heck reactions give access to functionalized alkenes by adding a substituent at the less substituted position of alkenes. Comparably, Heck-type substitution at a more substituted position of alkenes is less investigated and remains challenging.” In this work, his group effectively and successfully developed a unified protocol for metal-free cine-functionalizations of alkenes by thianthrenation.
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