• Prof. Gowravaram Sabitha (CSIR-Indian Institute of Chemical Technology, Hyderabad, India)

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Total Stereoselective Synthesis and Structural Revision of a γ-Lactone Polyketide of Fungal Origin

Gowravaram Sabitha reports the stereoselective synthesis and structural revision of a γ-lactone polyketide of fungal origin.

Stereoselective Synthesis of the Revised Structure of γ-Lactone Polyketide from Diaporthe sp. SXZ-19 and Its C-8 Epimer: K. S. N. Reddy, A. Y. Reddy, G. Sabitha
Synthesis 2016, 48, DOI: 10.1055/s-0035-1561463

A recently described γ-lactone polyketide originally isolated from the fungal strain Diaporthe sp. SXZ-19 of Camptotheca acuminata and its C-8 epimer were synthesized in stereoselective manner and their structure revised by Professor Gowravaram Sabitha and her colleagues from the CSIR-Indian Institute of Chemical Technology (Hyderabad, India).

  • Revised structures of polyketide γ-lactone and its C-8 epimer

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Professor Reddy – one of the article’s co-authors – said: “Synthesis of a γ-lactone polyketide has been achieved by utilizing Carreira, Ohira–Bestmann and alkyne–aldehyde coupling reactions.” 

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