• Synthesis of a Gallium Complexing Agent used in PET Tracers

    From left: Prof. K. Kopka, Dr. A. Makarem, Dr. C. Liolios, M. Konrad (German Cancer Research Center Heidelberg, Germany)

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Synthesis of a Gallium Complexing Agent used in PET Tracers

A Convenient Synthesis for HBED-CC-tris(tert-butyl ester): A. Makarem, M. Konrad, C. Liolios, K. Kopka
Synlett 2018, DOI: 10.1055/s-0036-1591950


PET tracers based on the 68Ga nuclide are used in clinical practice for the diagnosis of different cancers, such as neuroendocrine and prostate. The bifunctional complexing agent N,N′-bis[2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N′-diacetic acid (HBED-CC) is of particular interest as it is used in tracers such as 68Ga-HBED-PSMA which is currently regarded as the most efficient PET tracer for the detection of prostate cancer. Recently, Dr. Ata Makarem and collaborators at the German Cancer Research Center Heidelberg (Germany) reported a new convenient way to synthesize HBED-CC-tris(tert-butyl ester).

  • Synthesis of a Gallium Complexing Agent used in PET Tracers

    Synthesis for HBED-CC-tris(tert-butyl ester)

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Dr. Makarem said: “We have developed a convenient and cost-efficient procedure for the synthesis of HBED-CC-tris(tert-butyl ester). All the commercially available chemicals used in our synthetic protocol are relatively low-priced, and most reaction steps are short and easy to perform, also involving simple, fast and cost-efficient purification methods.”
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