From left: Dr. O. O. Grygorenko, M. Kurkunov, Dr. A. V. Tymtsunik (Enamine Ltd., Taras Shevchenko National University of Kyiv, National Technical University of Ukraine, Ukraine)zoom
Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks
Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks: O. O. Grygorenko, M. Kurkunov, I. A. Levandovskiy, A. V. Tymtsunik
Synthesis 2018, DOI: 10.1055/s-0037-1609434
Conformationally restricted scaffolds are valuable structural units in drug design and discovery. One interesting option is represented by bicyclic cyclobutane-derived heteroaliphatic templates, which have recently attracted increasing interest in different therapeutic areas. Recently, a team of scientists from the Ukraine reported a practical approach to the title structural templates, which holds promise to enable a facilitated access to a range of bioactive drug candidates incorporating 2-azabicyclo[n.2.0]alkane units.
Synthesis of 2-azabicyclo[n.2.0]alkane derivativeszoom