• From left: Prof. Antoni Riera, Ernest Salomó, Dr. Sílvia Orgué, and Prof. Xavier Verdaguer (Institute of Research in Biomedicine (IRB Barcelona) and University of Barcelona, Spain).

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Synthesis of Enantiopure tert-Butylmethylphosphine–Boranes

A Novel Entry to Enantiopure P-Stereogenic Ligands: tert-Butylmethylphosphine–Boranes.

Efficient Preparation of (S)- and (R)-tert-Butylmethylphosphine–Borane: A Novel Entry to Important P-Stereogenic Ligands: E. Salomó, S. Orgué, A. Riera, X. Verdaguer
Synthesis 2016, 48, DOI: 10.1055/s-0035-1561854

Enantiomerically pure phosphines are extremely important ligands for a wide range of catalytic enantioselective reactions, including stereoselective hydrogenations. However, their synthesis is often challenging and requiring ready access to suitable phosphorus-containing chiral intermediates, such as phosphine–boranes. The group of Professors Antoni Riera and Xavier Verdaguer from the Institute of Research in Biomedicine (IRB Barcelona) and the University of Barcelona (Spain) have reported a convenient entry to phosphine–boranes in both enantiomerically pure forms.

  • Synthesis of Enantiopure tert-Butylmethylphosphine–Boranes.

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Professors Antoni Riera and Xavier Verdaguer said: “This is an important P-stereogenic building block for phosphine ligand synthesis, and we hope that the novel methodology makes this compound readily available to the chemistry community.” 

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