• Rylan Lundgren describes the copper-catalyzed synthesis of N-arylsulfonamides.

    Dr. B. Ouyang (Nanchang Normal University, P. R. of China)

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Synthesis of N-Arylsulfonamides

Banlai Ouyang describes the copper-catalyzed synthesis of N-arylsulfonamides.

Synthesis of N-Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature: B. Ouyang, D. Liu, K. Xia, Y. Zheng, H. Mei, G. Qiu Synlett 2017, DOI: 10.1055/s-0036-1590978

The arylsulfonamide moiety is widespread among drugs and bioactive compounds. The classical and most used method for preparing the title compounds is the coupling between sulfonyl chlorides and aromatic amines which, however, are often highly toxic, carcinogenic and mutagenic. Recently, the group of Dr. Banlai Ouyang (Nanchang Normal University, P. R. of China), in collaboration with Dr. Guanyinsheng Qiu (Jiaxing University, P. R. of China), reported a new approach to the title compounds.

  • Rylan Lundgren describes the copper-catalyzed synthesis of N-arylsulfonamides.

    Copper-catalyzed synthesis of N-arylsulfonamides

      zoom
Professor Ouyang said: “A copper-catalyzed Chan–Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N-arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups.”
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