Synthesis of N,O-nucleosides via an Ene Reaction
Paolo Quadrelli presents the synthesis of N,O-nucleosides from (nitrosocarbonyl)mesitylene.
Synthesis 2017, 49, DOI: 10.1055/s-0036-1588695
The importance of nucleoside
Synthesis of N,O-nucleosides via an ene reactionzoom
Professor Quadrelli said:
“Sterically encumbered nitrosocarbonyl intermediates react with allylic alcohols and are able to activate the route towards 5-hydroxyisoxazolidines. These heterocycles are easily functionalized with a variety of heterobases and their biological behavior against several viruses as well as the potential apoptotic activities are actually investigated in collaboration with international research groups.”