A de novo Synthetic Route to 1,2,3,4-Tetrahydroisoquinoline Derivatives

Lórand Kiss presents a de novo synthetic route to 1,2,3,4-tetrahydroisoquinoline derivatives.

The group of Professor Loránd Kiss from the University of Szeged (Hungary) has a profound interest in the development of selective methods for the synthetic access to highly functionalized fluorinated saturated heterocycles and β-amino acid derivatives. Organofluorine chemistry is an expanding research field, having led to various applications of fluorine-containing compounds in organic synthesis, materials science, medicinal chemistry and drug discovery.

Because of the high biological relevance of compounds possessing the 1,2,3,4-tetrahydroisoquinoline framework, a large number of synthetic approaches towards the creation of an isoquinoline or 1,2,3,4-tetrahydroisoquinoline core are presently known. However, synthetic routes to tetrahydroisoquinoline derivatives containing fluorine atom(s) in their structure are not particularly abundant. The aim of the team from the laboratory of Professor Kiss was to fill this gap and develop effective synthetic methodologies to access varied fluorinated 1,2,3,4-tetrahydroisoquinoline derivatives.

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