• Loana Musso presents the synthesis of the tripeptide antibiotic resormycin.

    From left: Prof. S. Dallavalle, Dr. R. Kaduskar, Dr. L. Musso (Università degli Studi di Milano, Italy)

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Synthesis of the Tripeptide Antibiotic Resormycin

Loana Musso presents the synthesis of the tripeptide antibiotic resormycin.

Synthesis of the Tripeptide Antibiotic Resormycin: R. D. Kaduskar, A. Pinto, L. Scaglioni, L. Musso, S. Dallavalle Synthesis 2017, DOI: 10.1055/s-0036-1588553

Resormycin is a tripeptide metabolite of bacterial origin that was shown to have remarkable antibiotic activity. Resormycin is also an interesting synthetic target owing to the presence of three unnatural and unusual α-amino acids. Recently, a group of researchers led by Dr. Loana Musso from the Università degli Studi di Milano (Italy), reported an efficient approach to resormycin, which can also be used for structure–activity relationship studies on this class of antibiotic peptides.

  • Loana Musso presents the synthesis of the tripeptide antibiotic resormycin.

    Resormycin synthesis

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Dr. Musso said: “The straightforward synthesis of resormycin developed in our laboratory involves a late-stage stereospecific dehydration of a β-hydroxy amino acid to install the Z-olefin. Because of the modular nature of our synthetic strategy, ready access to partial structures and preparation of analogues sharing the tripeptide backbone core with resormycin are available.”
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