Charles Friedel (1832–1899) and James Mason Crafts (1839–1917): The Friedel–Crafts Alkylation and Acylation Reactions

This Name Reaction Biography presents Charles Friedel and James Mason Crafts and their alkylation and acylation reactions.

In 1877, the first two papers of a series of nine appearing over the following four years, were published by French chemist Charles Friedel, and his American collaborator James Mason Crafts. The reaction between a carbon electrophile and an aromatic hydrocarbon now bears the name of both chemists, and has become one of the foundational electrophilic aromatic substitution reactions. This article concentrates on the achievement of both chemists and gives background information on their biographies.


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