Total Synthesis of (±)-Atropurpuran

Plants of the genera Aconitum and Delphinium are widely distributed in the northern hemisphere and many of them have been employed in folk medicine to treat pain, rheumatism and neurological disorders. These species provide various groups of diterpenoid alkaloids possessing polycyclic and complex structures and a range of intriguing bioactivities. Professor Yong Qin’s group at Sichuan University (P. R. of China) began to study the total synthesis of atropurpuran in the summer of 2009 facing many challenges until the turning point for the project in March 2014 when they designed a different synthetic route, finally leading to success.

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