• Professor Nagamitsu (Kitasato University, Tokyo, Japan; left) with three of the co-authors of this study.


Total Synthesis of (+)-Clavulatriene A

Tohru Nagamitsu presents a protecting-group-free total synthesis of (+)-Clavulatriene A in SYNTHESIS.

Total Synthesis of (+)-Clavulatriene A: T. Nagamitsu and co-workers Synthesis 2015, DOI: 10.1055/s-0034-1379898

Professor Tohru Nagamitsu and co-workers from Kitasato University (Tokyo and Kanagawa, Japan) reported a protecting-group-free total synthesis of (+)-clavulatriene A, a cytotoxic diterpene metabolite produced by Streptomyces bacterial strains. The study also allowed for the determination of the absolute configuration of this molecule, which was previously unknown. Key step of the synthesis is a one-pot palladium-catalyzed reductive desulfonylation and deacetoxylation reaction.

Professor Nagamitsu said: “Practical strategies developed by our laboratory for the synthesis of (+)-clavulatriene A and α-cyperone have considerable potential for the generation of new analogues exhibiting useful biological activities.”

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