Total Synthesis of Tambromycin by Combining Chemocatalytic and Biocatalytic C–H Functionalization

Hans Renata shows a combination of chemo- and biocatalysis in the total synthesis of tambromycin.

Enzymes are capable of highly selective and specific synthetic transformations, but the potential of biocatalysis in total synthesis is far from being fully exploited. The lab of Professor Hans Renata at The Scripps Research Institute (USA) is broadly interested in developing novel synthetic approaches to bioactive natural products by leveraging contemporary technology in enzyme catalysis. They particularly focus on the use of enzymatic hydroxylation as an enabling platform to simplify routes to complex scaffolds. His group chose to work with iron- and α-ketoglutarate-dependent dioxygenases (Fe/αKGs) as their utility in organic synthesis has been relatively underexplored so far. The group was first drawn to tambromycin due to its structural complexity and promising preliminary bioactivity.


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