• Mark Stradiotto describes the synthesis of unsymmetrical biheteroaryls via Ni-catalyzed Suzuki–Miyaura cross-couplings.

    Left: Prof. M. Stradiotto, right: Stradiotto group, with Ryan Sawatzky on the far left (Dalhousie University, Canada)

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Unsymmetrical Biheteroaryls via Suzuki–Miyaura Cross-Couplings Using an Air-Stable Pre-Catalyst

Mark Stradiotto describes the synthesis of unsymmetrical biheteroaryls via Ni-catalyzed Suzuki–Miyaura cross-couplings.

(DPEPhos)Ni(mesityl)Br: An Air-Stable Pre-Catalyst for Challenging Suzuki–Miyaura Cross-Couplings Leading to Unsymmetrical Biheteroaryls: R. S. Sawatzky, M. Stradiotto
Synlett 2018, DOI: 10.1055/s-0036-1591523


The Suzuki–Miyaura (SM) coupling is one of the most used and versatile reactions in organic synthesis. However, the use of precious metal-based catalysts – such as Pd – represents a limitation, especially when the reaction needs to be performed on a large scale. Recently, the group of Professor Mark Stradiotto (Dalhousie University, Halifax, Canada) reported an interesting SM-type strategy for the synthesis of unsymmetrical biheteroaryls based on the use of an air-stable nickel pre-catalyst.

  • Mark Stradiotto describes the synthesis of unsymmetrical biheteroaryls via Ni-catalyzed Suzuki–Miyaura cross-couplings.

    Synthesis of unsymmetrical biheteroaryls via Suzuki–Miyaura cross-coupling

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Professor Stradiotto said: “The identification of ancillary ligands for use in enabling particularly challenging nickel-catalyzed cross-couplings represents an important challenge in synthetic chemistry. This article, along with a previous publication (Synlett 2017, 28, 1586), establishes DPEPhos as being highly effective for use in both C–N and C–C cross-coupling chemistry.”
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