Visible-Light-Induced Direct α C–H Functionalization of Alcohols
Aiwen Lei reports on the visible-light-induced α C–H functionalization of alcohols promoted by Selectfluor.
Alcohols are ubiquitous and widely used raw starting materials with broad applications in organic chemistry, the pharmaceutical industry and chemical engineering, to name just a few. For this reason, having ready access to a broad range of alcohols through the selective α C–H functionalization of alcohols would be of great significance. According to Professor Aiwen Lei from Wuhan University (P. R. of China), although much attention has been paid to the oxidative α sp³ C–H arylation of ethers with electron-deficient heteroarenes under a photocatalytic oxidation system, it is notable that the analogous reaction of alcohols had not yet been demonstrated. The Lei group has developed a visible-light-induced oxidative α sp³ C–H arylation of alcohols with heteroarenes, which is promoted by Selectfluor under blue LED irradiation.
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