Science of Synthesis

Your expert guide to making molecules

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Organic transformations at a glance


Science of Synthesis (SOS) is your online tool for comprehensive and quality organic synthesis reviews for the most reliable chemical transformations available.

It is the only resource available containing methods with full-text reviews by experts, experimental procedures and accurate and detailed reaction schemes.

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Your shortcut to the most reliable methods


SOS will provide you with synthetic methods including experimental procedures which are immediately applicable in the lab. All methods are clearly organized in a logical structure based on the functional group to be synthesized and can be explored in the context of other methods.

More than 2,000 selected experts are involved in the review and updating process, meaning that only the most reliable methods are included. SOS reviews include knowledge that you can't find anywhere else!

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How you can benefit from Science of Synthesis?

Find the most important organic transformations

Over 2,000 renowned experts select important topics, give a comprehensive review and keep the content up to date. Find out which method is useful for a particular route or not!

Get a comprehensive overview and save time

You need to work fast and efficiently? With its logical, systematic and consistent structure, SOS helps you to compare alternative methods and quickly select the best one for your needs.

Start with a synthesis immediately

Found your synthetic method of choice? In this case, you can start right away: effective and practical experimental procedures can be implemented directly in the lab.

Find out how Science of Synthesis improves your research!

Recommended by leading experts

Science of Synthesis not only provides data but in depth scientific context. It is a highly valuable, well reviewed and comprehensive source of knowledge for relevant topics in synthesis. Access to the content of Science of Synthesis should result in a better understanding of state of the art methodology and therefore is enabling high quality research in synthesis.

Dr. Guido Koch, Topadur Pharma AG, Switzerland

I strongly recommend Science of Synthesis because it not only provides an effective method to find information for your research, but also is a very useful textbook to organic chemists and graduate students. From SOS, you can easily find the history and development of the each type of reaction. Essential information, such as the reaction scope, limitation, mechanism, synthetic applications and experimental procedure are shown clearly in a well-organized version. Try it, I really believe you will find something different here.

Prof. Shuanhu Gao, East China Normal University, Shanghai, China

Science of Synthesis is an indispensable tome of chemical information organized in an intuitive and logical way. It contains information on nearly every aspect of chemical reactivity and, for me, is the "go-to" resource for rapidly learning about a new area. I use it regularly in preparation for classes and for consulting visits – it simply gives me the information I need far more easily than any search engine is capable of – and very often contains references and insight that cannot be found anywhere else.

Phil Baran, The Scripps Research Institute, La Jolla, CA, USA

Half century ago, the number of papers in organic synthesis is relatively limited and I was able to read most of these papers easily. However, the situation was changed drastically. The papers of organic synthesis are now publishing tremendous numbers and we could not cover every important paper. In fact, key papers are not so easy to find from these floods of papers. On the other hand, if we miss some of these most important information, we will be lost huge amount of research time. Science of Synthesis cover large number of synthesis topics which is far from the usual series of books of organic synthesis. From the large number of pages of SOS, we are able to find the most important information in relatively short time. I do hope you try to use SOS method to find out your required information in very short time. I believe the role of Science of Synthesis is even more important than before.

Hisashi Yamamoto, Chubu University, Japan

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